This bundle highlights practical, expert-driven approaches to infection prevention across diverse patient populations and care settings. It explores strategies to optimize outcomes for immunocompromised patients, integrates case-based learning, and addresses real-world challenges in reducing healthcare-associated infections. Sessions examine infection prevention in underrepresented environments—including psychiatric care, cystic fibrosis, and ambulatory settings—while offering solutions to common barriers and frontline pushback. Through expert insights and interactive discussion, participants gain actionable tools to strengthen infection control and antimicrobial stewardship in complex, high-risk settings.